WELCOME TO OUR COMPANY


Our History


  Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd is located in Boxing Economic Development Zone, Binzhou City,Shandong Province.

We are the largest manufacturer of engaged in cyclodextrin Pharmaceutical Excipients ,Cyclodextrin Reagents,Cyclodextrin Complex,Cyclodextrin Pmers in China.

●Jul  2010   Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd was established.

●Jun  2013  Have abtained ISO9001 certification.

●Mar  2014  Have obtained the drug production license.

●Mar  2015  Hydroxypropyl Betadex have obtained approval for the registration of

pharmaceutical excipients.

●May  2015  Sulfobutylether Betacyclodextrin Sodium Salt have obtained new drug

registration application.

●Dec  2015  Hydroxypropyl Betadex have approved by the U.S FDA,DMF NO.:030168

Betadex Sulfobutyl Ether Sodium have approved by the U.S FDA,

DMF NO.:030167

●Aug  2016 Betadex Sulfobutyl Ether Sodium have obtained drug clinical trial approval.

Our Factory

Business Type:Manufacturer 

Year Established: 2010 

Main Products:

●Medical Cyclodextrins

●Native Cyclodextrin

●Cyclodextrin Reagents,

●Cyclodextrin Complexes 

●Cyclodextrin Polymers.

Quality:

●Pharma grade

●Injection grade

●Industry grade  

●Cosmetics grade

●Food grade  

Complies Quality standards:

●CP standard

●USP standard

●JP standard

●EP standard

●Enterprise standard

●Customized according to customer needs personalized products and services;

Application: used in pharmaceutical ,cosmetics industries,food,ect.
Monthly production capacity: 200 tons

NUMBER OF EMPLOYEES WORKING IN THE PLANT

●Total Employees: 11 - 50 People

●No. of QA/QC Inspector(s): 6 People

●No. of Employees in Trade Department: 3-5 People

Certifications: ISO9001
Average Lead Time: 1-3 Days
Comprehensive production capacity: According to GMP standard production, the existing annual output of 300 tons;
Company philosophy: continuous improvement, access to user approval and  recommendation;

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Our Product

There are 5 series of cyclodextrin products:

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Classification

Product name

CAS

Medicinals Cyclodextrin

Hydroxypropyl-Beta-Cyclodextrin

128446-35-5

SODIUM SULFOBUTYL-ETHER-BETA-CYCLODEXTRIN

182410-00-0

Hydroxypropyl-Gamma-Cyclodextrin

128446-34-4

 Methyl-Beta-Cyclodextrin

128446-36-6

2,6-Di-O-methyl-Beta-cyclodextrin

51166-71-3

Native Cyclodextrin

Food grade Alpha-Cyclodextrin

10016-20-3

Beta-Cyclodextrin CAS 7585-39-9

7585-39-9

Pharma grade Gamma-Cyclodextrin

17465-86-0

Mercapto cyclodextrin

Mono-(6-Mercapto-6-deoxy)-β-cyclodextrin

81644-55-5

Hexakis-(6-mercapto-6-deoxy)-α-cyclodextrin

131105-41-4

Heptakis-(6-mercapto-6-deoxy)-β-cyclodextrin

30754-23-5

Octakis-(6-mercapto-6-Deoxy)-γ-cyclodextrin

168296-33-1

Amino beta cyclodextrin

Mono-(6-amino-6-deoxy)-β-cyclodextrin

29390-67-8

Heptakis(6-amino-6-deoxy)-β-cyclodextrin

30754-24-6

Iodo cyclodextrin

Hexakis-(6-iodo-6-deoxy)-α-cyclodextrin

131105-41-4

Heptakis-(6-iodo-6-deoxy)-β-cyclodextrin

30754-23-5

Octakis-(6-iodo-6-deoxy)-γ-cyclodextrin

168296-33-1

Azido beta cyclodextrin

Mono-(6-azido-6-deoxy)-beta-Cyclodextrin

98169-85-8

Heptakis-(6-azido-6-deoxy)-β-cyclodextrin

53958-47-7

Polyethylene polyamine modified β-cyclodextrin

Mono-(6-(diethylenetriamine)-6-deoxy)-beta-Cyclodextrin

65294-32-8

Mono-(6-((triethylenetetraamine)-6-deoxy)-beta-Cyclodextrin

65294-33-9

Mono-(6-(tetraethylenepentamine)-6-deoxy)-beta-Cyclodextrin

343315-27-5

Other Cyclodextrin Derivative

Carboxymethyl-beta-Cyclodextrin sodium salt

218269-34-2

Mono-(6-p-toluenesulfonyl)-Beta-cyclodextrin

67217-55-4

Mono-6-O-(p-toluenesulfonyl)-beta-cyclodextrin

67217-55-4

Mono-(6-ethanediamine-6-deoxy)-Beta-Cyclodextrin

60984-63-6

Mono-(6-(1,6-hexamethylenediamine)-6-deoxy)-Beta-Cyclodextrin

131991-61-2

Mono-(6-Hexanediamine-6-deoxy)-β-cyclodextrin

131991-61-2

allyl-β-cyclodextrin

N/A

Oligo(lactic acid)-Beta-Cyclodextrin

N/A

Hydroxypropyl-α-cyclodextrin

N/A

Hydroxybutyl-Beta-Cyclodextrin

N/A

Cyclodextrin Complexes

Piroxicam-beta-cyclodextrin

96684-39-8

Azelaic Acid-Hydroxypropyl-β-Cyclodextrin Complex

N/A

Menthol-Hydroxypropyl-Beta-Cyclodextrin Complex

N/A

Salicylic Acid-Hydroxypropyl-beta-Cyclodextrin Complex

N/A

Cyclodextrin Polymers

Soluble Beta Cyclodextrin Polymer Crosslinked

N/A

Beta Cyclodextrin Epichlorohydrin Copolymer

N/A

 

Product Application

Cyclodextrin derivatives are widely used in the following field:

●Applications:

Pharmaceuticals,

Cosmetics, flavor spices,

Fine chemicals,

Food,

Pesticides,

New materials field;

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Our Certificate

 

 

Picture

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Certificate Name

ISO9001

Issue Date

Mar.16,2017

Valid Date

Mar.15,2020

Certified By

ETC CERTIFICATION & TESTING CO.,LTD

Business Scope

Has been assessed as conforming to meet the requirments of:
Within Licensed Pharmaceutical Excipients-Hydroxypropyl Betadex / Betadex Sulfobutyl Ether Sodium etc; cyclodextrin Derivatives, cyclodextrin complexes, cycloswxtrin polymers and related service.

 

 Product Name

DMF NO.

Hydroxypropyl Betadex

030168

Betadex Sulfobutyl Ether Sodium

030167


Production Equipment

We have advanced production equipment as below:

Equipment name

Condition

K300L reaction kettle

Acceptable

K1000L reaction kettle

Acceptable

K2000L reaction kettle

Acceptable

K5000L reaction kettle

Acceptable

100L Double deck glass reaction kettle

Acceptable

Hollow fiber ultrafiltration device

Acceptable

The coil - type nanofiltration separation device

Acceptable

Spray drier

Acceptable

The coarse product Storage tank

Acceptable

Finished product Storage tank

Acceptable

Ultrafiltrate Storage tank

Acceptable

Double - stage reverse osmosis water treatment

Acceptable

Air conditioning purification unit

Acceptable

Clean workshop

Acceptable

  

Device name

Condition

High Performance Liquid Chromatography

Acceptable

Gas Chromatograph

Acceptable

Digital pH Meter

Acceptable

Digital Conductivity Meter

Acceptable

Muffle Stove

Acceptable

Electric Blast Oven

Acceptable

Constant Temperature Oil Bath

Acceptable

Micro Moisture Meter

Acceptable

Electronic Balance

Acceptable

Heated Incubators

Acceptable

Colony Count

Acceptable

Oscillator

Acceptable

Stability Test Chamber

Acceptable

Incubator

Acceptable

Biochemical incubator

Acceptable

Mold Incubator

Acceptable

Biological Safety Cabinets

Acceptable

  

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Participate in industry exhibitions every year

API Shanghai on 18st-20th Apr,2016 

  This exhibition have promoted the customer relationship,fully display the enterprise image, improve the product brand value.Hydroxypropyl beta cyclodextrin has won fifth star products of pharmaceutical excipients on 76th API Shanghai exhibition.

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CPHI Shanghai on 20st-22th JUN,2017 

  This exhibition expand the company and product visibility, expand the market channels, mining the key customers, consolidate the relationship between with old customers, to improve employee morale, obviously increase the sales.

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Production Market

CPHI India on 28st-30th NOV,2017 

  CPHI Indian exhibition effect is very good, many clients come to our stall for meeting & further discussion cyclodextrin .

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Our service

Competitive Advantage of service

Rich experience.
  We have experienced foreign trade personnel in cyclodextrin field, professional knowledge can help customers choose the correct products, be familiar with the import policies of various countries can help customers avoid risks. Fluent English can communicate with customers better and provide documents to customers timely We have established long business relationship with many customers
 
Conforms to multiple quality standards and competitive price:
  Raw Material-Material Storage-Workshop Production-Finished Product-Finished Product Storage-Sale-After sale service,in the whole prcess,our product is under the supervision of QA and QC,firmly conforms to GMP standard.

Conforms to multiple quality standards can meet the requirements of different customers.Welcome order the samples, MOQ just 50 grams.Factory direct sale,so price is competitive.
 
Safest and fastest delivery:
  We have mass stock, so that we can arrange the delivery within 24hours once receiving the  
payment. Tracking number would be informed quickly after shipment. We have our own way of
packing which could ship 0.05 kilo to 50 kilo products a time.
 
Good after-sales service.
  We will tell you Cargo updated information ASAP. And try our best to solve various problems customers encountered!
 

  Binzhou Zhiyuan Biotechnology covers an area of 30.5 acres,Construction area of 5200 square meters,46 million yuan in fixed assets,The total number of employees 41 people,Bachelor degree or above 13 people,R & D technical staff 10 people;The existing four major categories of 45 varieties of products;Various types of cyclodextrin production capacity of 800 tons per year,The actual output of about 150 tons,Annual sales income 20 million yuan.

We are a leading manufacturer and supplier of cyclodextrin derivatives in China.We have 5 series (Medical Cyclodextrins, Cyclodextrin Reagents, Cyclodextrin Complexes,

Cyclodextrin Polymers ) of more than 40 kinds of cyclodextrins now. Hydroxypropyl Betadex and Betadex sulfobutyl ether sodium have approved by The U.S. FDA.


  We have advanced production lines and testing equipments,such as HPLC,GC,CE,IC,IR and so on. Strictly following GMP, the product quality meets the multiple standards such as CP, USP,EP, JP.  

Expect to cooperate with you by providing the first-class products and high-quality service.