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Application of cyclodextrin in medicine

- Aug 10, 2018 -

In 1891, the French scientist A.villiers accidentally isolated a new metabolite, cyclodextrin, when the starch was digested with microorganisms. The fat-soluble drug molecules could be incorporated into the hydrophobic cavity of the cyclodextrin. Host-guest inclusion complex, this inclusion compound can greatly improve the physical and chemical properties of drug molecules, such as: increase the water solubility, stability of the drug, improve bioavailability and reduce adverse reactions. Since about 40% of clinical drugs and about 90% of the drugs under study have water solubility problems, the use of cyclodextrin as a pharmaceutical excipient to improve pharmacological properties has received increasing attention.

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