Among the many cyclodextrin derivatives, hydroxypropyl beta cyclodextrin is the most attractive compound. Its solubility is more than 70%, and its inclusion ability is equivalent to betacyclodextrin. According to the related animal experimental data, HPBD is safe, peritoneal and intravenous administration (15g/kg) are not toxic, 50% of the solution has no irritation to skin, eyes and muscles, and its toxicity is not greater than glucose. Therefore, HPBD is regarded as one of the most application prospect of beta cyclodextrin hydrophilic derivative.
Hydroxypropyl betac yclodextrin is one of the main raw materials for transdermal drug delivery. It can increase the absorption of active substances by skin. Its mechanism of promoting permeation is different from other penetration enhancers. It can improve the thermodynamic activity of drug molecules and increase the drug permeability by increasing the concentration of free drug in the water-based medium on the surface of biofilm without changing the local mucosal tissue structure. Therefore, in cosmetics, we can draw lessons from the preparation principle of transdermal drug delivery preparations, using the characteristics of hydroxypropyl betacyclodextrin to increase the skin absorption of effective ingredients in products, improve the use of products.