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Application of hydroxypropyl-beta-cyclodextrin in the field of Medicine

- Dec 06, 2018 -

Increasing Water Solubility of Insoluble Drugs

HP-beta-CD is soluble in water. The solubility of HP-beta-CD is generally greater than 50g/100mL at room temperature, or even more than 80g/100mL. When the concentration is less than 40%, it has good fluidity and low viscosity. Used in pharmaceutical industry can improve the solubility of drugs without using organic solvents, surfactants and lipids. The water solubility of insoluble drugs can be significantly increased by enveloping them. The concentration of HP-beta-CD increases linearly with the concentration of HP-beta-CD after the drug complexes with HP-beta-CD.

Increasing drug stability and bioavailability

During the storage of drugs, they are affected by many factors such as light, heat and humidity, which directly affect the quality of drugs. Therefore, stability is an important index for investigation. HP-beta-CD can prevent the volatilization, sublimation, oxidation and photolysis of drugs when they are encapsulated in holes.

The drug encapsulated with HP-beta-CD can dissolve quickly and release quickly, and can increase the absorption of drugs by organisms, which is conducive to improving the bioavailability of drugs.

Reducing toxicity and side effects of drugs

The toxicity and irritation of insoluble drugs to human body can be significantly reduced by the combination of collateral and drug delivery routes.

Hydroxypropyl-beta-cyclodextrin can be used in oral medicines, injections, mucosal delivery systems (including nasal mucosa, rectum, cornea, etc.), transdermal absorption delivery systems, lipophilic targeting drug carriers, as well as protectants and stabilizers of proteins.


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