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Cyclodextrin can inclusion glutathione

- Nov 29, 2018 -

Glutathione is a natural active peptide composed of glutamate, cysteine and glycine.Glutathione is usually found in reduced glutathione (GSH) and oxidized glutathione (GSSG) forms.Generally, only GSH has biological activity, But  the mercapto group of GSH is easily oxidized in aqueous solution and air, which becomes GSSH, thus losing physiological activity. It is hoped that appropriate binding agent can be used to inclusion GSH to ensure that the mercapto group is not oxidized, thus improving the bioavailability of glutathione.

It has been confirmed that Glu residues of GSH can be encapsulated by caprospaces of alpha cyclodextrin to form stable complexes.The sulfhydryl group on GSH in this complex is bound by the large end of alpha -CD, thus effectively protecting it from oxidation.The results show that alpha -CD is a good glutathione binding agent.

alpha cyclodextrin

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