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Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd
Add:Boxing Economic Development Zone, Binzhou, Shandong, China
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Tripterygium wilfordii hydroxypropyl beta cyclodextrin

- Dec 13, 2018 -

Tripterygium wilfordii extract has the functions of dispelling wind and dampness, activating blood circulation and dredging collaterals, relieving swelling and pain, insecticide and detoxification, etc. It is used for the symptoms of wind-cold and dampness arthralgia, swelling and poisoning of furuncles, waistband sores, skin itching, etc.

The commonly used preparation process is to extract the root, bark, stem, leaf or other parts of Tripterygium wilfordii with water, then extract the water extract with chloroform, and recover the chloroform from Tripterygium wilfordii extract. Then the extract was mixed into ethanol solution, hydroxypropyl beta-cyclodextrin was mixed into water solution, and Tripterygium wilfordii solution was added into hot hydroxypropyl beta-cyclodextrin aqueous solution under stirring, stirring and cooling, and hydroxypropyl beta-cyclodextrin inclusion compound of Tripterygium wilfordii extract was precipitated. The inclusion complex has significant curative effect on rheumatoid arthritis, chronic nephropathy, lupus erythematosus, psoriasis and so on, with little side effects.

Hydroxypropyl beta-cyclodextrin has excellent hydrophilicity, so Triptolide and other fat-soluble components can be completely soluble in water after being made into cyclodextrin inclusion complex. It is easy to make injections, oral liquids and other water-solvent preparations. It is also easy to press tablets and try other formulations completely.

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