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Hydroxypropyl beta cylcyclodextrin combined with panax notoginseng

- Oct 25, 2018 -

Panax notoginseng (PNS) is the active ingredient of panax notoginseng in panax family. It has pharmacological effects such as dilating blood vessels, reducing oxygen consumption of myocardium, prolonging coagulation time and regulating immunity, and is mainly used in the treatment of cardiovascular and cerebrovascular diseases. In recent years, with the deepening of its research, it has been found to have anti-cancer effect, so more and more attention has been paid to it. Due to its characteristics of strong irritation, bitter taste and easy moisture absorption, the clinical application of PNS is limited to a certain extent.

Hydroxypropyl beta cylodextrin is a non-polar tubular cavity with hydrophobic inner wall and hydrophilic outer wall, which can form a inclusion compound with different types of molecules similar in polarity and matching in molecular size with the cavity. Hydroxypropyl beta cylodextrin not only encapsulates the active ingredients in the drug, but also ACTS as a drug carrier to remove the active ingredients in the drug. At the same time, it ACTS as a drug carrier to eliminate the odor of the drug and improve its bioavailability.

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