DMF No.: 030168
Name: hydroxypropyl- beta-cyclodextrin
Other name : hydroxypropyl betadex; 2-hydroxypropyl-beta-cyclodextirn; Hydroxypropyl-β-cyclodextrin.
Abbreviation : HP-β-CD
CAS: 128446-35-5; 94035-02-6
Molecular formula :C42H70-nO35(C3H8O2)n
Molecular weight: 1134.98+58n
Qaulity ： Pharma grade /injection grade/ food grade / cosmetics grade / industry grade
Standard : USP39/ EP9.0/ CP2015
Package: 500g/bag , 2kg/bag, 10kg/drum , 20kg/drum or customized
Injection grade hydroxypropyl-beta-cyclodextrin can only be used in injection-grade drugs.
Oral grade hydroxypropyl-beta-cyclodextrin can be used in oral medicine.
1. To increase the solubility of medicine and biological availability
2. To improve the bio availability of drugs.
3. To adjust or control the releasing of drugs.
4. To decrease the toxicities of drugs.
5. To improve the stabilities of drugs.
Hydroxypropyl beta cyclodextrin is an ideal injection solubilizer and drug excipients because of lower surface activity and hemolytic activity and no muscle irritation.
Hydroxypropyl beta cyclodextrin is not only be used in oral drugs, injection, mucosal drug delivery system, transdermal drug delivery system, lipotropy targeting drug carrier, but also can be used as protein protective agent and stabilizer. Meanwhile, it can control drug release rate, lower drug toxicity and enhance stability. In pharmaceuticals industry,hydroxypropyl Cyclodextrin can increase the solubility of the medicine and biological availability, also add up the good effect and decrease the dose.
Hydroxypropyl Beta Cyclodextrin can increase solubility and bioavailability of insoluble drugs, so that the efficacy of drugs can last longer with less ingestion of drugs. It can adjust and control drugs release ratio, decrease side effects of drugs, and enhance stability of drugs. It can be used for oral medication, injection, mucosal delivery systems (including the nasal mucosa, rectum, cornea, etc. ), dermal drug delivery systems, lipophilic drugs targeting delivery, and also used as protective agent and stabilizer of protein.