Betadex Sulfobutyl Ether Sodium
Name: Betadex Sulfobutyl Ether Sodium CAS: 182410-00-0 Molecular formula: C 42 H 70-n O 35 (C 4 H 8 O 3 S Na)n Molecular weight: 1135+158n Quality: Injection grade Standard: USP40 Package: 500g/bag,1kg/bag,10kg/drum or customized The role in ophthalmic medicine Betadex sulfobutyl ether sodium...Send InquiryChat Now
Name: Betadex Sulfobutyl Ether Sodium
Molecular formula: C42H70-nO35(C4H8O3S Na)n
Molecular weight: 1135+158n
Quality: Injection grade
Package: 500g/bag,1kg/bag,10kg/drum or customized
Clarity of Solution
A 30%w/v solution in water is clear and essentially free from particles of foreign matter
Same absorption bands as USP betadex sulfobutyl ether sodium RS
Identify test are positive for Sodium
the retention time of the major peak of sample solution corresponds to the standard solution
Average Degree of Substitution
SBE 1 Content
SBE III Content
SBE IV Content
SBE V Content
SBE VIII Content
Water solution pH
pH of 30%w/v solution in water is 4.0-6.8
Disodium bis-(4-sulfobtyl) ether
TAMC ( cfu/g)
TYMC ( cfu/g)
Packaging and storage
Preserve in well-closed containers and store at room temperature.
Protect from moisture.
The role in ophthalmic medicine
Betadex sulfobutyl ether sodium has little stimulation on cornea and can reduce the irritation of drugs on the eyeball, so it is very suitable for the preparation of eye drops with physiological pH and osmotic pressure requirements.
Ganciclovir was soluble in water, but the water solubility was significantly affected by pH, more easily in dissolved under acidic conditions. The pH and osmotic pressure of the eyedrops are strictly required. The results showed that the Betadex sulfobutyl ether sodium in the prescription significantly reduced the eye irritation of ganciclovir, and the inclusion of Betadex sulfobutyl ether sodium on the drug could increase the biocompatibility of the eye drops.
O,O’-Dipropionyl-(1,4-xylylene) bispilocarpate is a precursor of trabeculin, a drug for glaucoma treatment. It has a strong irritation to the eye and affects its clinical application. After adding Betadex sulfobutyl ether sodium to the prescription of the eye drops, it was found that the irritation of Betadex sulfobutyl ether sodium eye drops to rabbit eyes was significantly reduced within the range of 24 ~ 36mmol. L-1. The mechanism may be that when the drug forms a inclusion compound with Betadex sulfobutyl ether sodium, the inclusion compound can slowly release the drug in the eye, so as to reduce the local concentration of the free drug and reduce or eliminate the eye irritation caused by the rapid absorption or precipitation of the drug.