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Sulfobutyl Ether Beta Cyclodextrin Sodium Salt FDA

Sulfobutyl Ether Beta Cyclodextrin Sodium Salt FDA

Name: Sulfobutyl ether-beta-cyclodextrin sodium salt Other name : Betadex sulfobutyl ether sodium ; Sulfobutyl ether-β-cyclodextrin sodium salt CAS No.: 182410-00-0 Abbreviation: SBEBCD Molecular formula : C42H70-nO35 (C4H8O3S Na)n Molecular weight: 1135+158n

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Product Details

DMF No.: 030167

Name: Sulfobutyl ether-beta-cyclodextrin sodium salt  

Other name : Betadex sulfobutyl ether sodium ; Sulfobutyl ether-β-cyclodextrin sodium salt

CAS No.: 182410-00-0

Abbreviation: SBE-β-CD

Molecular formula : C42H70-nO35 (C4H8O3S Na)n

Molecular weight: 1135+158n

Qaulity:Injection grade

Standard : USP40

Package: 500g/bag , 1kg/bag , 2kg/bag, 10kg/drum , 20kg/drum or customized

A 30% w/v solution in water is clear and essentially free from particles of foreign matter

Average Degree of Substitution :6.2-6.9


Sulfobutyl-β-cyclodextrin is an anionic high water-soluble cyclodextrin derivative, which can be well combined with drug molecules to form a non-covalent complex, thereby improving the stability, water solubility and safety of the drug. Reduce nephrotoxicity, ease drug hemolytic, control drug release rate, mask bad odor, etc.


It has been applied to injectables, oral drugs, nasal medications, and ocular medications, and has special affinity and inclusion for nitrogen-containing drugs.


Product performance

1. Neutral, positive and negative drug substances can be effectively combined with sulfobutyl beta-cyclodextrin to increase the solubility of compounds in the drug solution by 10 to 25,000 times.

2. Sulfobutyl betacyclodextrin has good biocompatibility and can be administered by injection, oral, ocular, nasal, topical and inhalation.

3. Normally, it can be quickly and completely eliminated from the kidneys after administration. In vitro and in vivo acute, subacute and chronic toxicity studies provide safe data and are approved for use in human pharmaceutical preparations.

4. The interaction with sulfobutyl beta-cyclodextrin provides a beneficial protective environment for the drug substance in its lipophilic cavity, while the hydrophilic surface provides excellent water solubility to provide solubility and stability.


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