Borneol, is often used as "drug introduction and adjuvant", which can promote the absorption of local drugs and penetrate the blood-brain barrier. There are many compatible applications of Borneol in traditional Chinese medicine. Borneol is widely used in cardiovascular and cerebrovascular treatment, but it is easy to sublimate, which makes the preparation process and storage period extremely unstable.
The inclusion of borneol with cyclodextrin can greatly improve the stability and water solubility of borneol, especially the inclusion effect of hydroxypropyl beta-cyclodextrin (HP-beta-CD) is much better than that of beta-cyclodextrin. The inclusion of HP-beta-CD-borneol provides a more reliable and effective way of preparation for the treatment of cardiovascular and cerebrovascular diseases with traditional Chinese medicine. It is more advantageous to the preparation with less side effects, especially to the preparation of water-soluble injection from borneol.
After hundreds of experiments, the R&D team of Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. has successfully tested the inclusion compound of borneol-hydroxypropyl beta-cyclodextrin and obtained customer approval.